El virus que causa covid-19, conocido como SARS-CoV-2, ingresa en las células de la nariz y los pulmones a través de la unión de su proteína de punta a la proteína de la superficie celular, enzima convertidora de angiotensina 2. Esa proteína del virus, también llamada espiga, reconoce a la ACE2 como su receptor para ingresar a las células.
La terapia con interferón, aunque parece aumentar los niveles de la proteína ACE2, incrementa también considerablemente los niveles de una versión corta de esa proteína, a la que el virus no puede unirse, según investigadores de la Universidad de Southampton.
La revista científica señala que las expertas Jane Lucas, Donna Davies, Gabrielle Wheway y Vito Mennella, de la Universidad inglesa de Southampton y del Hospital Universitario Southampton han identificado una nueva forma breve de ACE2. Las proteínas antivirales naturales llamadas interferones se han mostrado prometedoras en el tratamiento de la covid-19.
Sin embargo, estudios anteriores han indicado que los interferones aumentan los niveles de ACE2, por lo que había dudas sobre el potencial de tales tratamientos, con la posibilidad de que un aumento de ACE2 pueda hacer que estos medicamentos empeoren los impactos de la covid-19.
Dado que los niveles de la forma más prolongada de ACE2 permanecen sin cambios, los interferones no parecen estimular los puntos de entrada del virus, lo que respalda su uso en el tratamiento de pacientes con covid-19.
Esto ayuda a explicar los resultados prometedores de un ensayo de un tratamiento con interferón beta inhalado para pacientes con covid-19, desarrollado por un equipo de Southampton.
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